Equine viral arteritis (EVA) is an acute contagious viral disease of equids caused by equine arteritis virus (EAV) Typical cases are characterized by fever depression anorexia leukopenia dependent edema (especially of the lower hind extremities scrotum and prepuce in the stallion) conjunctivitis supra- or periorbital edema nasal discharge respiratory distress skin rash temporary In our study the largest horse (Horse 4) was the most severely affected (Table 1) and therefore dose dependency warrants further investigation Because experimental infection with ECoV is relatively novel comparison to epidemiological studies is necessary 4 5 In outbreaks in both the United States and Japan many horses became systemically

ficial American Thoracic Society Workshop Report: Use of

including horses (16 17) donkeys (18) cats (19) and West Highland white terriers (20) Horses develop fibrosis after experimental gherpesvirus infection (21) but none of the other animals have been proven as tractable models of experimental fibrosis Furthermore no therapies have been proven to alter the course of fibrosis in

Experimental models in the investigation of device-related infections By Werner Zimmerli Download PDF (312 KB) prophylaxis and treatment of device-related infection In addition by using this infection model novel microbiological in-vitro tests could be developed and questions of biocorn-patibility analyse Year: 2017

The English summary appended to the paper is as follows: - Septicaemia with Clostr botulinum Type A was reproduced in 8 guineapigs For the purpose of avoiding intoxication the inoculation was made by three times washed bacilli of 24-hour culture of Clostr botulinum It was established that the virulence of the initiator shows an inconsiderable growth until the death of the infected

Jun 25 2016The pathogenic mechanism of equine recurrent uveitis (ERU) is still poorly defined and many variations between experimental animal models and spontaneous disease exist Objectives The aim of our study was to investigate if Th17 cell-mediated response plays role in the pathogenesis of the used experimental model in horses and to reveal its

T1 - Central nervous system demyelination in Venezuelan equine encephalomyelitis infection An experimental model of virus-induced myelin injury AU - Dal Canto Mauro C AU - Rabinowitz Stanley G PY - 1981/3 Y1 - 1981/3 N2 - Arboviruses are important pathogens for both animals and humans

Validation of a new experimental model for assessing drug

Validation of a new experimental model for assessing drug efficacy against infection with Trypanosoma equiperdum in horses Highlights•Intravenous injection of T equiperdum induced a reproducible dourine-like infection •Cervical sampling is a suitable tool for detecting trypanosomes in equine CSF •T equiperdum parasites were detected in equine CSF 12 5 1 6 days post infection

Acclimatization Infection Study period Treatment −21 −5 0 2 7 10 14 21 28 35 42 56 70 73 120 Treatment groups allocated Figure 1: Experimental design for S neurona infection study Following a 2-week acclimation nine horses had baseline neurologic

Nov 15 2018The present study reports on the development of an experimental infection model for assessing drug efficacy against the nervous form of dourine The model combines the infection of horses by Trypanosoma equiperdum and the search for trypanosomes in the cerebrospinal fluid (CSF) through an ultrasound-guided cervical sampling protocol

Validation of a new experimental model for assessing drug efficacy against infection with Trypanosoma equiperdum in horses Highlights•Intravenous injection of T equiperdum induced a reproducible dourine-like infection •Cervical sampling is a suitable tool for detecting trypanosomes in equine CSF •T equiperdum parasites were detected in equine CSF 12 5 1 6 days post infection

The English summary appended to the paper is as follows: - Septicaemia with Clostr botulinum Type A was reproduced in 8 guineapigs For the purpose of avoiding intoxication the inoculation was made by three times washed bacilli of 24-hour culture of Clostr botulinum It was established that the virulence of the initiator shows an inconsiderable growth until the death of the infected

An experimental model was developed to study the clinical infection in nave healthy ponies (ERAV/ON/05 n=4 and placebo n=4) ERAV/ON/05 induced clinical respiratory disease compared to placebo The clinical signs consisted of pyrexia nasal discharge increased and abnormal lung sounds increased size of submandibular lymph nodes and

Fenger CK Granstrom DE Gajadhar A et al Experimental induction of equine protozoal myeloencephalitis in horses using Sarcocystis sp sporocysts from the opossum (Didelphis iana) Vet Parasitol 68:199-213 1997 MacKay RJ Serum antibodies to Sarcocystis neurona-half the horses in the United States have them! JAVMA 210:482-483 1997

horses: pregnant mares delivered normal foals after an outbreak at a breeding farm in India Horses recover fully within approximately 1-2 weeks Getah virus may also be pathogenic in swine In a few cases fetal deaths were reported after natural or experimental infection of sows Some experimentally

Investigation of the Stochastic Choice under Risk using

The parameters are estimated in each model using a maximum likelihood technique and run a horse-race using the goodness-of-fit between the models The results show that the RUM better explains the subjects' behaviour in the experiment Additionally the RDEU fits better than the EU for modelling the stochastic choice

Experimental models in the investigation of device-related infections By Werner Zimmerli Download PDF (312 KB) prophylaxis and treatment of device-related infection In addition by using this infection model novel microbiological in-vitro tests could be developed and questions of biocorn-patibility analyse Year: 2017

encephalomyelitis [en-sef″ah-lo-mi″ĕ-litis] inflammation of the brain and spinal cord acute disseminated encephalomyelitis an acute or subacute encephalomyelitis or myelitis occurring most commonly following an acute viral infection especially measles but sometimes occurring without a recognizable antecedent Clinical manifestations include

In this work we consider the use of a mixed effects differential equations model and the use of a stochastic agent based model to model data from competition infection experiments of Equine Infectious Anemia Virus (EIAV) EIAV is a retrovirus that presents with a lifelong persistent infection

Noninfectious respiratory disease is a common performance-limiting condition that affects adult horses of various ages Inflammatory airway disease is characterized by excessive tracheal mucus airway hyperreactivity and poor exercise performance in young horses The etiology is unclear but viral respiratory infection (EHV-2) allergy and environmental factors may play a role in the

Dec 05 2013Equine herpesvirus myeloencephalitis (EHM) remains one of the most devastating manifestations of equine herpesvirus type 1 (EHV-1) infection but our understanding of its pathogenesis remains rudimentary partly because of a lack of adequate experimental models EHV-1 infection of the ocular vasculature may offer an alternative model as EHV-1-induced chorioretinopathy appears to

Mar 01 2018Screening of Model Animals for Experimental Infection with Equine Cyathostomes The attempt to transfer cyathostome larvae was aimed at developing a model for the investigation of different aspects of the life cycle and biology of these nematodes in the laboratory Some animals were immunized (hydrocortisone) for the duration of the study

Sweeney RW Uzonna J Whitlock RH Habecker PL Chilton P Scott P Tissue predilection sites and effect of dose on Mycobacterium avium subs paratuberculosis organism recovery in a short-term bovine experimental oral infection model Research in Veterinary Science 80: 253-9 2006

Studies in murine experimental models have shown that both the parasite and host genotypes are crucial for tissue distribution and pathophysiology of infection by T cruzi It has been previously reported that 81% of the Mexican strains of T cruzi belong to lineage TcI and have different capabilities of infection virulence and processing

ErnstFehr – Experimental Behavioral Economics 6 My Speculation • Experimental economics is essentially a method of empirical investigation If successful the method will become a standard instrument in economist's toolbox • Behavioral economics is concerned with importing relevant insights from other disciplines to economics

The most common symptoms of infection are fever and joint pain Other symptoms may include headache muscle pain joint swelling or rash Outbreaks have occurred in countries in Africa Asia Europe and the Indian and Pacific Oceans In late 2013 chikungunya virus was found for the first time in the Americas on islands in the Caribbean