Weight loss on drying GPM 1 2 1 0010 15 Replaces the State Pharmacopoeia of the Russian Federation XI Monograph The present General Pharmacopoeia Monograph describes the method used to determine weight loss on drying for medicinal products and immunobiologicals The term Weight loss on drying means the weight loss due to hygroscopic 2 2 32 Loss on drying 0 01 % 2 5 12 Water : Semi-Micro Determination 0 01 % United States Pharmacopoeia 39th Edition : 2016 Physical Tests/ 731 Loss on Drying 0 01 % Physical Tests/ 921 Water Determination 0 01 % The Japanese Pharmacopoiea 17th Edition : 2016 General Tests/ 2 41 Loss on Drying Test 0 01 % General Tests/ 2 48

Rapid Method for Moisture Content in Sodium Chloride Salt

by Loss on Drying (LOD) or by Karl Fischer (KF) titration Both methods have pros and cons in terms of accuracy precision speed and ease of measurement For example KF titration is routinely used in quality control laboratories and is labor intensive time consuming and uses toxic chemicals [4] The LOD method on the other hand is not very

Usp 731 loss on drying monographs Loss on drying usp 731 pdf Compare Search ( Please select at least 2 keywords ) Most Searched Keywords Road king dash panel insert 1 American mod insurance 2 Windows display driver model 2 2 3 Glucagon stimulation test cpt 4

Jan 28 202011 0 Test – Loss on drying The drying procedure of the LOD bottle Sample weight temperature and time of drying sample Two constant weights (if required) and calculation 12 0 Test – Limit test/appearance of solution /acidity and alkalinity Observation the countersignature of another person who has checked the sample in the lab

can be also done by loss on drying (USP 731 Chapter) as long as the total loss on drying is less than the maximum acceptable limit for class 3 resid-ual solvents (5000 ppm) USP general procedures do not relate to specif-ic solvents but they try to compromise chromato-graphic and headspace conditions in

It is not appropriate to use Loss on Drying (LOD) if the amount of class 3 solvent exceeds 0 5% In those cases gas chromatography should be used If you have process validation information indicating that you can reduce the amount of class 3 solvent to 0 5% or lower in the final product you can discuss with FDA the possibility of using LOD

Understanding the Revisions to USP Monograph 467

Class 3 solvents may be determined by 731 Loss on Drying unless the level is expected to be 5000 ppm or 50 mg If the loss on drying is 0 5 % then a water determination should be performed using 921 Water Determination The monograph allows the use of alternative methodologies as long as they have been appropriately validated

Nov 02 2019Loss on drying (LOD) is the simplest and oldest technique for residual moisture analysis and may be performed without any specialized laboratory equipment The sample is removed from the vial and weighed into a dried container USP 731 "Loss on Drying" (US Pharmacopeial Convention Rockville MD 2019) 6 USP 891 "Thermal

Jan 28 202011 0 Test – Loss on drying The drying procedure of the LOD bottle Sample weight temperature and time of drying sample Two constant weights (if required) and calculation 12 0 Test – Limit test/appearance of solution /acidity and alkalinity Observation the countersignature of another person who has checked the sample in the lab

and Loss on Drying 731 This method is not if for items in which the loss may include volatiles other than water • For Biologics see the individual monograph • For Botanicals See Articles of Botanical Origin 561 Method II is the azoeotropic distillation of water by toluene: • Anhydrous Toluene Omnisolv AX0732 or Sigma-Aldrich 244511

Loss on drying 731 — Dry at 120 to constant weight: the hydrous form loses between 38 0% and 41 0% of its weight and the anhydrous form loses not more than 1 0% of its weight Insoluble matter— Dissolve the equivalent of 20 g of anhydrous sodium acetate in 150 mL of water heat to boiling and digest in a covered beaker on a steam bath for

Loss on Drying (LOD) Loss on drying is a widely used test method to determine the moisture content of a sample although occasionally it may refer to the loss of any volatile matter from the sample Loss in drying does not usually refer to molecularly bound water or water of crystallisation

Loss on Drying (Percentage Dry Weight) The percentage weight loss when sediment is dried is determined by the sediment composition Generally sediments with a high organic content weigh less when dried than an equivalent wet weight of sediment with a high mineral content Equipment Clean dry porcelain crucibles spatula balance weighing to 4

Loss on drying using the conditions recommended by the manufacturer of the equipment Manufacturers of SDS-PAGE equipment may provide gels of different surface area and thickness Electrophoresis running time and current/voltage may need to vary as described by the manufacturer of the apparatus in order to achieve optimum separation Check that the

Loss on Drying / Loss on Ignition

Loss on Drying (LOD) Loss on drying is a widely used test method to determine the moisture content of a sample although occasionally it may refer to the loss of any volatile matter from the sample Loss in drying does not usually refer to molecularly bound water or water of crystallisation

Hi Q1: I want to analyse Loss on drying in Dried Factor VIII Fraction as per IP Here is the method suggested Loss on drying determined by drying 0 5 g over phosphorus pentoxide at a pressure not exceeding 3 kPa for 24 hours My question is how can i dry over phosphorous pentoxide? means how to prepare the set-up for the same

Loss on drying 731 — Dry it at 145 for 4 hours: it loses not more than 5 0% of its weight Loss on ignition 733 — Ignite about 1 g of it previously dried and accurately weighed at 1000 for not less than 1 hour: it loses not more than 8 5% of its weight

Loss on drying 731 — Dry at 120 to constant weight: the hydrous form loses between 38 0% and 41 0% of its weight and the anhydrous form loses not more than 1 0% of its weight Insoluble matter— Dissolve the equivalent of 20 g of anhydrous sodium acetate in 150 mL of water heat to boiling and digest in a covered beaker on a steam bath for

8 2 Loss on Drying 731 and Water Determination 921 8 3 Microbial limit test 8 4 Antimicrobial agent test 8 5 Bacterial endotoxins 8 6 Melting Range or Temperature 741 8 7 Degree of polymerization 9 Additional Requirements 9 1 Packaging and storage 9 2 Labeling 9 3 Other requirements 9 4 Reference Standards 10 Formulas C

USP 731 (Loss on Drying) AOAC and ISO describe the thermogravimetric method using a drying oven as a standard procedure for determining moisture content A Valid Alternative to the Drying Oven An alternative thermogravimetric procedure that provides comparable results to the drying oven in a considerably faster time is conducting loss on

The heading Loss on drying (see Loss on Drying 731 ) is used in those cases where the loss sustained on heating may be not entirely water Change to read: METHOD I (TITRIMETRIC) Determine the water by Method Ia unless otherwise specified in the

fewest decimal places under Loss on Drying 〈731〉 which must be included in the EXAMPLE— calculations of amounts and concentrations of ingredients The pharmacist should consider the effect of ambient hu-11 5 + 11 65 + 9 90 = 33 1 midity on the gain or loss of water from drugs and added substances in containers subjected to intermittent

May 14 2019A direct loss on drying method with no requirement for calibration Temperature preprograming Conclusion The SMART Q represents the state-of-the-art for loss on drying methodology in the pharmaceutical and food industries and is fully able to provide equivalence with USP 731

Modified* USP Monograph 731: Loss on Drying Method Modified* USP Monograph 921: Water Determination Method *USP Monograph 731 and 921 indicate that a drying temperature of 105 C should be utilized In order to avoid loss of volatile organic compounds during the drying process an oven temperature of 80 C was chosen for the analysis of cannabis